Welcome to the Center for Integrated Systems Genomics at UNC (CISGen)

Autism, Depression, Anxiety, Antipsychotic drug side effects- What are the genetic and environmental factors that underlie and contribute to these complex phenotypes? And how do genes and environment interact to shape them?

In 2009, CISGen was funded by NIMH and NHGRI as one of ten Centers of Excellence in Genome Sciences (CEGS) to tackle some of the least tractable problems in biomedicine. The mission of the Centers is to conduct highly innovative research designed to develop new concepts, methods, technologies, that will substantially advance genomic approaches to biological problems. A group of diverse investigators at UNC have aligned their expertise in mouse/human genetics, mouse behavior, psychiatry, statistical genetics, computational biology, and systems biology to delineate the genetic and environmental determinants of complex phenotypes drawn from psychiatry. The platform that forms the basis of the project is the Collaborative Cross (CC) panel of recombinant inbred mice, which was developed as a tool to model the heterogeneous human population. This population surmounts many of the limitations encountered in human studies, GWAS, and other available mouse resources. CISGen will collect detailed genomic and phenotypic data to interrogate the genomic search space and identify potentially complex genetic effects, interactions, pathways, and networks. High probability models will then be tested for their predictive ability. CISGen data and computational tools will provide a valuable resource to the wider scientific community with applications to a large array of biological problems.

CISGen integrates three major aims that are described in detail in the project pages:

1. Genomic Characterization of CC and CC-RIX MICE

2. Behavioral Phenotyping and Pharmacogenomics

3. Statistical Analysis and Modeling

4. Data Management and Visualization

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